The Game and Playe of the Chess</em>, William Caxton
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First Florentine period 1464/69 - 1481/83

Leonardo may have completed the Annunciation during this year.

Birth of Isabella d’Este, one of the great art patrons and collectors of the Renaissance in Italy.

In Bruges, William Caxton prints the first book in English, The Game and Playe of the Chess.