Roman period 1513 - 1516

On 25th September Leonardo is in Parma, and on the 27th on the banks of the Po river, probably as engineer to Giuliano de’ Medici, Captain General of the papal militia.

Under Giuliano’s instigation, Leonardo becomes involved in plans to drain the malarial Pontine marshes south of Rome. On 8th October Leonardo is inscribed in the Confraternity of S. Giovanni dei Fiorentini in Rome.

Leonardo designs improvements for the port of Civitavecchia and in December, a project to drain the malarial Pontine marshes south of Rome.

Birth of Andreas Vesalius, Flemish anatomist, who produced the first systematic study of anatomy based on careful observation and dissection. He was the author of the first major illustrated book on anatomy, De Humani Corporis Fabrica, published in 1543.

Death of Donato Bramante.